反応 #172149

反応方程式

NaOH

mixture

tert-Butyl trans-6,7,7a,8,10,10a-hexahydropyrido[3,2-c]pyrrolo[3,4-e]azepine-9(5H)-carboxylate

triethylamine

3,4-Dichlorobenzene-1-sulfonyl chloride

→

title compound

tert-Butyl trans-6-[(3,4-dichlorophenyl)sulfonyl]-6,7,7a,8,10,10a-hexahydropyrido[3,2-c]pyrrolo[3,4-e]azepine-9(5H)-carboxylate

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他the dichloromethane layer was separated
2. 2
   workup.ADDITIONtreated with water (2 mL)
3. 3
   乾燥dried over Na2SO4
4. 4
   その他The solvent was removed in vacuo

実験手順

A mixture of Example 334B (100 mg, 0.34 mmol) and triethylamine (0.097 mL, 0.69 mmol) in dichloromethane (2 mL) was stirred at ambient temperature for 10 minutes. 3,4-Dichlorobenzene-1-sulfonyl chloride (0.52 mmol, 1.5 equivalents) was added, and the reaction mixture was stirred at room temperature overnight. A 10% NaOH solution (2 mL) was added; the dichloromethane layer was separated, treated with water (2 mL) and dried over Na2SO4. The solvent was removed in vacuo to give the title compound.

出典