反応 #172030

反応方程式

(R)-2-amino-3-cyclopropylpropanoic acid

NaOH

Di-tert-butyl carbonate

→

(R)-2-(tert-butoxycarbonylamino)-3-cyclopropylpropanoic acid

収率 56.3%

溶媒

water

Ethanol

water

THF

反応条件

後処理

1. 1
   抽出extracted with ether
2. 2
   その他the aqueous layer was separated
3. 3
   抽出the aqueous layer was extracted with EtOAc, organic layer
4. 4
   その他was separated
5. 5
   洗浄washed with brine
6. 6
   その他dried
7. 7
   濃縮concentrated

実験手順

To a solution of (R)-2-amino-3-cyclopropylpropanoic acid (1.0 g, 7.7.4 mmol) in Ethanol (15 mL) and water (8 mL) was added 1N NaOH (10 mL) and Di-tert-butyl carbonate (1.86 g, 8.52 mmol) in THF (8 mL). After stirring at room temperature for 15 h, the solution was diluted with water, extracted with ether, the aqueous layer was separated and was acidified to pH 2 with conc. HCl, the aqueous layer was extracted with EtOAc, organic layer was separated, washed with brine, dried and concentrated to give (R)-2-(tert-butoxycarbonylamino)-3-cyclopropylpropanoic acid (1.0 g).

出典