反応 #172017

反応方程式

Water

2-bromo-4,5-difluorobenzonitrile

tert-butyl (1S,2R)-2-aminocyclohexylcarbamate

DIEA

→

tert-butyl (1S,2R)-2-(5-bromo-4-cyano-2-fluorophenylamino)cyclohexylcarbamate

収率 93.4%

溶媒

DMSO

反応条件

後処理

1. 1
   その他precipitation
2. 2
   その他The precipitate was collected
3. 3
   その他dried on vacuum

実験手順

A solution of 2-bromo-4,5-difluorobenzonitrile (218 mg, 1.00 mmol), tert-butyl (1S,2R)-2-aminocyclohexylcarbamate (214 mg, 1.00 mmol) and DIEA (0.300 mL, 1.72 mmol) in DMSO (2 mL) was stirred at 100 C for 18 h. Water was added to induce precipitation. The precipitate was collected and dried on vacuum to give tert-butyl (1S,2R)-2-(5-bromo-4-cyano-2-fluorophenylamino)cyclohexylcarbamate as a solid (385 mg).

出典