反応 #171998

反応方程式

2-bromo-4-fluorobenzonitrile

D-phenylalanine amide

DIEA

→

(R)-2-(3-bromo-4-cyanophenylamino)-3-phenylpropanamide

収率 23.3%

溶媒

DMSO

反応条件

後処理

1. 1
   その他The mixture was then purified by HPLC

実験手順

A solution of 2-bromo-4-fluorobenzonitrile (255 mg, 1.27 mmol), D-phenylalanine amide (220 mg, 1.34 mmol) and DIEA (0.466 mL, 2.68 mmol) in DMSO (3 mL) was stirred at 100 C for 18 h. The mixture was then purified by HPLC to give (R)-2-(3-bromo-4-cyanophenylamino)-3-phenylpropanamide (102 mg).

出典