反応 #171958

反応方程式

Compound 3

N-(2-methylbenzothiazole-6-sulfonyl)piperidine

p-toluenesulfonic acid methyl ester

→

Compound 4

収率 86.0%

N-(2,3-dimethylbenzothiazole-6-sulfonyl)piperidine tosylate

収率 86.0%

反応条件

後処理

1. 1
   温度to cool to room temperature
2. 2
   その他the resulting mass was triturated with acetone (25 ml) until a gray colored solid
3. 3
   その他separated
4. 4
   その他The solid was collected by centrifugation
5. 5
   洗浄washed with acetone
6. 6
   その他dried under vacuum

実験手順

A mixture of Compound 3 (1.0 g, 3.4 mmol) and p-toluenesulfonic acid methyl ester (0.94 g, 5.1 mmol) was heated in a pressure tube at 130° C. for 1 hour. The mixture was allowed to cool to room temperature, and the resulting mass was triturated with acetone (25 ml) until a gray colored solid separated. The solid was collected by centrifugation, washed with acetone and dried under vacuum to yield 1.4 g (86%) of Compound 4 whose structure is given below:

出典