反応 #1718602

反応方程式

dimethyl 5-hydroxy-isophthalate

potassium carbonate

1,1,1,2,2,3,3-heptafluoro-3-(1,2,2-trifluorovinyloxy)propane

→

Dimethyl 5-(1,1,2-trifluoro-2-(perfluoropropoxy)ethoxy)isophthalate

溶媒

THF

THF

反応条件

後処理

1. 1
   その他equipped with a condenser, mechanical stirrer
2. 2
   workup.ADDITIONaddition funnel
3. 3
   洗浄to wash all the reagents into the reaction vessel
4. 4
   温度The resulting mixture was refluxed for 10.5 hours

実験手順

Anhydrous THF (12 liters) and dimethyl 5-hydroxy-isophthalate (2100 g) were combined under nitrogen in an oil jacketed 22 liter RB flask equipped with a condenser, mechanical stirrer, pressure equalizing addition funnel. To this stirred solution was added anhydrous potassium carbonate (1035 g), followed by 1,1,1,2,2,3,3-heptafluoro-3-(1,2,2-trifluorovinyloxy)propane (3192 g). Ca. 2 liters of additional THF was used to wash all the reagents into the reaction vessel. The resulting mixture was refluxed for 10.5 hours.

出典