反応 #171584

反応方程式

ethyl-4-bromobutyrate

3-bromophenol

K2CO3

Sodium iodide

→

ethyl 4-(3-bromophenoxy)butanoate

溶媒

water

acetone

反応条件

後処理

1. 1
   温度cooled to room temperature
2. 2
   抽出extracted with ethylacetate

実験手順

Solid 3-bromophenol (10.0 g, 58 mmol) was added portion wise to a stirred suspension of K2CO3 in acetone (100 mL) at room temperature. Sodium iodide (NaI, 1.0 g) was added, followed by ethyl-4-bromobutyrate (9.2 mL, 64 mmol). The reaction mixture was heated at 80° C. overnight, cooled to room temperature, diluted with water and extracted with ethylacetate to give ethyl 4-(3-bromophenoxy)butanoate 6.

出典