反応 #171559

反応方程式

125

tert-Butyl (6-(7-(2-fluoro-4-nitrophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl(2-methoxyethyl)carbamate

NH4Cl

→

title compound 126

収率 100.0%

tert-Butyl (6-(7-(4-amino-2-fluorophenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl(2-methoxyethyl)carbamate

収率 100.0%

溶媒

EtOH water

反応条件

後処理

1. 1
   温度at reflux for 1 hour
2. 2
   ろ過The reaction mixture was then filtered through a celite pad
3. 3
   濃縮concentrated

実験手順

A solution of 125 (443 mg, 0.80 mmol) and NH4Cl (37 mg, 0.68 mmol) in 2:1 mixture of EtOH/water (10.5 mL) was treated with iron powder (380 mg, 6.79 mmol) and stirred at reflux for 1 hour. The reaction mixture was then filtered through a celite pad and concentrated to afford title compound 126 that was used without further purification (440 mg, 100% yield). MS (m/z): 525.2 (M+H).

出典