反応 #1711438

反応方程式

urocanic acid

→

solid

収率 96.0%

3-(1H-imidazol-4-yl)-propionic acid

収率 96.0%

溶媒

H2O

反応条件

後処理

1. 1
   その他The catalyst was removed by filtration
2. 2
   濃縮the filtrate was concentrated in vacuo

実験手順

A suspension of urocanic acid (2.00 g, 14.5 mmol) in H2O (40 mL) was shaken at room temperature with a suspension of 10% Pd/C (200 mg, 0.19 mmol) under hydrogen atmosphere (30 psi) for 2 h. The catalyst was removed by filtration, and the filtrate was concentrated in vacuo to give a colourless solid (1.95 g, 96%). 1H NMR (D2O) δ 2.52 (t, 2H, J=7.2 Hz), 2.92 (t, 2H, J=7.2 Hz), 7.16 (s, 1H), 8.49 (s, 1H).

出典