反応 #170955

反応方程式

Ethyl bromoacetate

paracetamol

K2CO3

→

1

収率 80.1%

(4-Acetylamino-phenoxy)-acetic acid ethyl ester

収率 80.1%

溶媒

acetone

反応条件

後処理

1. 1
   温度refluxed for 16 hours
2. 2
   workup.DISTILLATIONAcetone was distilled
3. 3
   workup.ADDITIONwater (5 L) was added
4. 4
   ろ過Crude 1 was filtered
5. 5
   その他dried
6. 6
   その他recrystallised from a mixture of toluene:hexane (1:5)

実験手順

Ethyl bromoacetate (452 g, 2.7 mol.) was added to a mixture of paracetamol (300 g, 1.984 mol) and anhydrous K2CO3 (1.80 kg, 7.814 mmol) in anhydrous acetone (3 L) and refluxed for 16 hours. Acetone was distilled and water (5 L) was added. Crude 1 was filtered, dried and recrystallised from a mixture of toluene:hexane (1:5) to give pure 1 (377 grams, 80%) as a white shining powder. The melting point was found to be 104.2-106.2° C.

出典