反応 #1708

反応方程式

Compound 25

6-methyl-5,7-dipropoxy-2-pyridin-3-ylmethlene-3,4-dihydro-2H-naphthalen-1-one

hydrogen

→

Compound 26

収率 68.5%

6-Methyl-5,7-dipropoxy-2-(pyridin-3-ylmethyl)-1,2,3,4-tetrahydronaphthalen-1-one

収率 68.5%

溶媒

methanol

反応条件

後処理

1. 1
   ろ過the reaction was filtered
2. 2
   濃縮concentrated in vacuo

実験手順

A mixture of Compound 25 (3.96 g, 10.8 mmol) and 10% palladium on carbon (600 mg) in abs. methanol (100 mL) was hydrogenated at 1 atm for 12 hr. The hydrogen was replaced with nitrogen, the reaction was filtered and concentrated in vacuo. Chromatography of the residue on silica gel (elution with 20% ethyl acetate:hexanes) provided 2.72 g of Compound 26.

出典