反応 #170690

反応方程式

2-methylenepentanedioic acid dimethyl ester

2,4-dimethoxybenzylamine

→

titled compound

1-(2,4-Dimethoxybenzyl)-6-oxopiperidine-3-carboxylic acid methyl ester

溶媒

toluene

反応条件

後処理

1. 1
   温度at reflux
2. 2
   洗浄washed with a 1M aqueous solution of hydrochloric acid, water
3. 3
   乾燥a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate
4. 4
   濃縮concentrated under reduced pressure

実験手順

To a solution of 2-methylenepentanedioic acid dimethyl ester (19.2 g) in toluene (195 ml) was added 2,4-dimethoxybenzylamine (16.6 ml), and the mixture was stirred for 3 days at reflux. This reaction solution was cooled to room temperature, and then washed with a 1M aqueous solution of hydrochloric acid, water and a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give a crude product of the titled compound (26.8 g).

出典