反応 #170664

反応方程式

2-methyl-3-methylenesuccinic acid dimethyl ester

2,4-dimethoxybenzylamine

→

titled compound

収率 174.1%

4-methyl-5-oxopyrrolidine-3-carboxylic acid

収率 174.1%

溶媒

toluene

反応条件

後処理

1. 1
   温度at reflux
2. 2
   その他purified by silica gel column chromatography (eluent: n-hexane/chloroform=1/1 to 0/1)

実験手順

To a solution of 2-methyl-3-methylenesuccinic acid dimethyl ester (9.81 g) in toluene (100 ml) was added 2,4-dimethoxybenzylamine (9.72 g) and the mixture was stirred for 3 days at reflux. This reaction solution was cooled to room temperature and then purified by silica gel column chromatography (eluent: n-hexane/chloroform=1/1 to 0/1) to give the titled compound (14.2 g).

出典