反応 #1706107

反応方程式

1-(2,2-Dimethylpropyl)-5-nitro-1H-1,2,3-benzotriazole

→

titled compound

1-(2,2-dimethylpropyl)-1H-1,2,3-benzotriazol-5-amine

溶媒

ethanol

反応条件

後処理

1. 1
   その他sparged under nitrogen
2. 2
   その他sparged under hydrogen (1 atm)
3. 3
   ろ過the mixture was filtered through Celite
4. 4
   洗浄the residue was washed with MeOH
5. 5
   濃縮The filtrate was concentrated in vacuo

実験手順

1-(2,2-Dimethylpropyl)-5-nitro-1H-1,2,3-benzotriazole (4.46 g, 19.0 mmol, 1.0 equiv.) was dissolved in ethanol (50 ml), sparged under nitrogen, charged with 10% Pd/C (2.03 g, 1.90 mmol, 0.1 equiv.) and then sparged under hydrogen (1 atm). After stirring at room temperature for 5 hrs, the mixture was filtered through Celite and the residue was washed with MeOH. The filtrate was concentrated in vacuo to provide the titled compound. LRMS m/z (M+H) 205.0 found, 205.3 required.

出典