反応 #170511

反応方程式

6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid

(R)-(−)-leucinol

→

title compound

収率 49.0%

N—((S)-1-Hydroxymethyl-3-methyl-butyl)-6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinamide

収率 49.0%

反応条件

実験手順

As described for example 191, 6-(5-methyl-3-phenyl-isoxazol-4-ylmethoxy)-nicotinic acid (200 mg, 0.65 mmol) was converted, using (R)-(−)-leucinol instead of 2-aminoethyl isopropylether, to the title compound (130 mg, 49%) which was obtained as a white solid. MS: m/e=408.4 [M−H]−.

出典