反応 #1704435

反応方程式

water

(4-mercaptophenyl)methanol

2-amino-5-bromo-6-methylpyrimidin-4-ol

HCl

→

subtitle compound

2-Amino-5-(4-(hydroxymethyl)phenylthio)-6-methylpyrimidin-4-ol

溶媒

ethylene glycol

反応条件

後処理

1. 1
   温度After cooling the mixture
2. 2
   ろ過The precipitate was filtered
3. 3
   洗浄washed with water
4. 4
   乾燥50% EtOH/ether and dried

実験手順

A stirred mixture of (4-mercaptophenyl)methanol (6.72 g), 2-amino-5-bromo-6-methylpyrimidin-4-ol (10.76 g) and K2 CO3 (7.29 g) in ethylene glycol (120 ml) was heated at 155° C. for 9 h. After cooling the mixture was poured into water (500 ml) and neutralised with conc. HCl. The precipitate was filtered, washed with water then 50% EtOH/ether and dried to give the subtitle compound as a solid, 6.7 g. 1H NMR DMSO-d6: δ11.07 (brs, 1H); 7.18 (d, 2H); 6.99 (d, 2H); 6.87 (brs, 2H); 5.09 (s, 1H); 4.41 (s, 2H); 2.24 (s, 3H)

出典