反応 #1704434

反応方程式

product

2-(4-((2-Amino-4-chloro-6-methylpyrimidin-5-yl)methyl)phenyl)acetonitrile

(S)-3-aminohexan-1-ol

butan-1-ol

KOH

→

subtitle compound

(S)-2-(4-((2-Amino-4-(1-hydroxyhexan-3-ylamino)-6-methylpyrimidin-5-yl)methyl)phenyl)acetic acid

反応条件

後処理

1. 1
   その他was sealed into a microwave tube
2. 2
   その他was performed in the CEM Microwave, at 160° C.
3. 3
   温度The mixture was cooled
4. 4
   その他the solvent evaporated under reduced pressure
5. 5
   その他The residue was purified by RPHPLC

実験手順

A mixture of the product of example 81 step (iii) (0.4 g) and (S)-3-aminohexan-1-ol (0.5 g) in butan-1-ol (3 mL) was sealed into a microwave tube. The reaction was performed in the CEM Microwave, at 160° C. and 100 W for 1.5 h. Aq. 5M KOH (iml) was added and the mixture heated at 100° C. for 48 h. The mixture was cooled and the solvent evaporated under reduced pressure. The residue was purified by RPHPLC to give the subtitle compound, 174 mg.

出典