反応 #170418

反応方程式

6-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid

rac-6-oxa-3-aza-bicyclo[3.1.1]heptane

→

title compound

収率 22.0%

{6-[3-(4-Fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-pyridin-3-yl}-(1R,5S)-6-oxa-3-aza-bicyclo [3.1.1]hept-3-yl-methanone

収率 22.0%

反応条件

実験手順

As described for example 105, 6-[3-(4-fluoro-phenyl)-5-methyl-isoxazol-4-ylmethoxy]-nicotinic acid (36 mg, 0.11 mmol) was converted, using rac-6-oxa-3-aza-bicyclo[3.1.1]heptane instead of 2,2,2-trifluoroethylamine, to the title compound (10 mg, 22%) which was obtained as a colourless gum. MS: m/e=410.4 [M+H]+.

出典