反応 #1702104

反応方程式

lithium hydroxide monohydrate

THF

HCl

→

(1S)-4-methyl-cyclohex-3-enecarboxylic acid

収率 91.0%

溶媒

water

methanol

反応条件

後処理

1. 1
   抽出The mixture was extracted with hexanes
2. 2
   乾燥ethyl acetate (200 mL: 15 mL), dried over sodium sulfate
3. 3
   ろ過filtered
4. 4
   濃縮concentrated to 2.4 g of a white semi-solid
5. 5
   workup.DISSOLUTIONThe residue was redissolved in hexanes
6. 6
   洗浄dichloromethane (100 mL, 95:5), washed with water
7. 7
   乾燥dried over sodium sulfate
8. 8
   ろ過filtered

実験手順

4-Methyl-cyclohex-3-(S)-enecarboxylic acid 4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester (3.34 g, 13.2 mmol) in THF (25 mL), water (2.5 mL) and methanol (2.5 mL) was treated with lithium hydroxide monohydrate (2.8 g, 66.2 mmol) and warmed to 50° C. with stirring. After 1 h, the reaction mixture treated with 1M HCl (about 25 mL). The mixture was extracted with hexanes:ethyl acetate (200 mL: 15 mL), dried over sodium sulfate, filtered and concentrated to 2.4 g of a white semi-solid. The residue was redissolved in hexanes:dichloromethane (100 mL, 95:5), washed with water, dried over sodium sulfate, filtered and concentrated to 1.68 g (91% yield) of (1S)-4-methyl-cyclohex-3-enecarboxylic acid as a white powder.

出典