反応 #1702094

反応方程式

(2-Benzyloxycarbonylamino-ethyl)-methyl-phosphinic acid ethyl ester

EtOH

→

(2-amino-ethyl)-methyl-phosphinic acid ethyl ester

収率 90.0%

溶媒

EtOAc

反応条件

後処理

1. 1
   その他was run at room temperature
2. 2
   ろ過The reaction was then filtered through Supercell NF
3. 3
   濃縮the filtrate was concentrated

実験手順

(2-Benzyloxycarbonylamino-ethyl)-methyl-phosphinic acid ethyl ester (1.3 g, 4.56 mmol) and 10% Pd/C (485 mg) were combined in a flask and EtOH (46 mL) was added. The reaction flask atmosphere was exchanged for H2 and the reaction was run at room temperature until complete, as determined by TLC (eluent: 100% EtOAc). The reaction was then filtered through Supercell NF and the filtrate was concentrated to yield (2-amino-ethyl)-methyl-phosphinic acid ethyl ester (615 mg, 90%) as a yellow oil in which white crystals began to form under high vacuum.

出典