反応 #1702073
ord-a8b5dcdd27e04124891270579f140223
反応方程式
反応物
試薬
反応条件
後処理
- 1抽出extracted by ethyl acetate
- 2洗浄The organic layer was washed by water
- 3乾燥a saturated sodium hydrogen carbonate aq. solution and a saturated saline solution, dried over magnesium sulfate
- 4濃縮concentrated under reduced pressure
- 5その他The crude product was purified by silica gel chromatography
実験手順
The synthesis process is as set forth in the chemical reaction formula below. The CAN in the reaction path stands for cerium ammonium nitrate. To 5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-methylnaphthalene (b) (202 mg, 1.00 mol) were added acetic acid (8.2 mL) and cerium ammonium nitrate (2.40 g, 4.37 mol) followed by stirring at 100° C. for 1 hour. The reaction solution was poured into ice water and extracted by ethyl acetate. The organic layer was washed by water, a saturated sodium hydrogen carbonate aq. solution and a saturated saline solution, dried over magnesium sulfate, and concentrated under reduced pressure. The crude product was purified by silica gel chromatography using hexane/ethyl acetate (15/1) as an elution solvent. The yield was 106 mg (49%).