反応 #1702055

反応方程式

(3R)-3-{4-[2-(morpholine-4-sulfonyl)-ethyl]-phenyl}-cyclopentanone

(1R)-1-(4-fluoro-3-methoxyphenyl)ethylamine hydrochloride

→

(1R/S,3R)—N-[(1R)-1-(4-fluoro-3-methoxy-phenyl)ethyl]-3-[4-(2-morpholinosulfonylethyl)phenyl]cyclopentanamine

反応条件

実験手順

General procedure B was followed using (3R)-3-{4-[2-(morpholine-4-sulfonyl)-ethyl]-phenyl}-cyclopentanone (preparation 49) as the ketone and (1R)-1-(4-fluoro-3-methoxyphenyl)ethylamine hydrochloride as the amine. 1H NMR (300 MHz, DMSO) δ 7.23-7.04 (m, 6H), 6.92-6.83 (m, 1H), 3.82 (s, 3H), 3.80-3.68 (m, 1H), 3.66-3.55 (m, 4H), 3.37-3.26 (m, 2H), 3.22-3.10 (m, 4H), 3.06-2.78 (m, 4H), 2.20-1.13 (m, 6H), 1.23 (d, J=6.6 Hz, 3H).

出典