反応 #1702053

反応方程式

(3R)-3-{4-[2-(morpholine-4-sulfonyl)-vinyl]-phenyl}-cyclopentanone

→

(3R)-3-{4-[2-(Morpholine-4-sulfonyl)-ethyl]-phenyl}-cyclopentanone

溶媒

EtOAc

反応条件

後処理

1. 1
   workup.WAITwas hydrogenated over night at r.t
2. 2
   ろ過The mixture is filtered
3. 3
   その他solvents are removed in vacuo
4. 4
   その他to afford the 1H NMR (300 MHz, CDCl3) δ 7.25-7.17 (m, 4H), 3.75 (m, 4H), 3.48-3.34 (m, 1H), 3.32-3.23 (m, 4H), 3.21-3.07 (m, 4H), 2.72-2.61 (m, 1H), 2.53-2.22 (m, 4H), 2.01-1.89 (m, 1H)

実験手順

A solution of (3R)-3-{4-[2-(morpholine-4-sulfonyl)-vinyl]-phenyl}-cyclopentanone (210 mg) in EtOAc (10 ml) containing Pd/C (10%, 50 mg) was hydrogenated over night at r.t. The mixture is filtered and solvents are removed in vacuo to afford the 1H NMR (300 MHz, CDCl3) δ 7.25-7.17 (m, 4H), 3.75 (m, 4H), 3.48-3.34 (m, 1H), 3.32-3.23 (m, 4H), 3.21-3.07 (m, 4H), 2.72-2.61 (m, 1H), 2.53-2.22 (m, 4H), 2.01-1.89 (m, 1H).

出典