反応 #1702046

反応方程式

Water

CDI

(R)-[4-(3-Oxo-cyclopentyl)-phenoxy]-acetic acid

Ammonium hydroxide

→

title compound

収率 81.0%

2-[4-[(1R)-3-Oxocyclopentyl]phenoxy]acetamide

収率 81.0%

溶媒

DMF

反応条件

後処理

1. 1
   その他a precipitate formed
2. 2
   ろ過the precipitate filtered off
3. 3
   その他dried in vacuo

実験手順

(R)-[4-(3-Oxo-cyclopentyl)-phenoxy]-acetic acid (preparation 31) (1.6 mmol, 375 mg) was dissolved in DMF (3 mL), then CDI (1.84 mmol, 299 mg) was added and the reaction mixture stirred at r.t. for 90 min. Ammonium hydroxide (25% aq, 7 mL) was added and a precipitate formed. Water (7 mL) was added and the precipitate filtered off and dried in vacuo to yield the title compound (302 mg, 81%). 1H NMR (300 MHz, CDCl3) δ 7.25-7.14 (m, 2H), 6.97-6.83 (m, 2H), 6.78 (bs, 1H), 5.91 (bs, 1H), 4.49 (s, 2H), 3.52-3.28 (m, 1H), 2.77-2.57 (m, 1H), 2.57-2.11 (m, 5H), 2.09-1.79 (m, 1H).

出典