反応 #1702042

反応方程式

lithium aluminum hydride

ether

sodium potassium tartrate

hydrogen

5-Norbornene-2-carbonitrile

ether

→

5-Norbornene-2-methanamine

溶媒

water

反応条件

後処理

1. 1
   その他A three-neck flask is equipped with mechanical stirrer
2. 2
   温度reflux condenser
3. 3
   その他produces a clear solution
4. 4
   その他The reaction solution is transferred to a separatory funnel
5. 5
   その他the aqueous phase is collected
6. 6
   洗浄washed with 3×50 ml portions of ether
7. 7
   乾燥The combined ether fractions are dried with calcium sulfate and solvent
8. 8
   その他is removed by rotary evaporation
9. 9
   その他yielding a yellow oil
10. 10
    workup.DISTILLATIONThis product is further distilled under reduced pressure
11. 11
    その他to yield a clear oil

実験手順

A three-neck flask is equipped with mechanical stirrer, reflux condenser and dropping funnel. The flask is charged under N2, with 42 ml of a 1.0 M solution of lithium aluminum hydride in anhydrous ether (42 mmol). A solution of 5 g of 5-Norbornene-2-carbonitrile (bicyclo[2.2.1]hept-5-ene-2-carbonitrile) in 45 ml of ether (42 mmol, 1.0 M) is added dropwise through the addition funnel at a rate that allows a gentle reflux. After one hour, the mixture is cooled to 0° C. and water is added dropwise until hydrogen gas liberation is no longer observed. To this, 100 ml of 20% sodium potassium tartrate is added and produces a clear solution. The reaction solution is transferred to a separatory funnel, and the aqueous phase is collected and washed with 3×50 ml portions of ether. The combined ether fractions are dried with calcium sulfate and solvent is removed by rotary evaporation yielding a yellow oil. This product is further distilled under reduced pressure to yield a clear oil.

出典