反応 #1702

反応方程式

tert-butyl propiolate

ethyl α-aminooximinoacetate

xylene

→

tert-butyl 2-ethoxycarbonylimidazole-4-carboxylate

溶媒

triethylamine

反応条件

後処理

1. 1
   その他The crude product (19 g) is chromatographed on a silica column
2. 2
   洗浄eluting with a mixture of cyclohexane and ethyl acetate (50-50 by volume)

実験手順

tert-Butyl 2-ethoxycarbonyl imidazole-4-carboxylate can be prepared as follows: the procedure is as in Example 1 but starting from 15 g of ethyl α-aminooximinoacetate, 500 ml of xylene, 19.1 of triethylamine and 14.3 ml of tert-butyl propiolate. The crude product (19 g) is chromatographed on a silica column, eluting with a mixture of cyclohexane and ethyl acetate (50-50 by volume) to give 5 g of tert-butyl 2-ethoxycarbonylimidazole-4-carboxylate, employed as such in the subsequent syntheses.

出典