反応 #170135

反応方程式

tert-butyl 3-(1,3-thiazol-2-ylmethoxy)azetidine-1-carboxylate

tert-Butyl 3-(1,3-thiazol-2-ylmethoxy)azetidine-1-carboxylate

HCl

→

title compound

2-[(Azetidin-3-yloxy)methyl]-1,3-thiazole hydrochloride

溶媒

diethyl ether

diethyl ether

反応条件

後処理

1. 1
   濃縮then concentrated to dryness
2. 2
   その他The resulting solid was triturated with diethyl ether
3. 3
   その他collected
4. 4
   その他dried

実験手順

To a solution of tert-butyl 3-(1,3-thiazol-2-ylmethoxy)azetidine-1-carboxylate (193 mg, 0.71 mmol; which may be prepared as described in Step 2) dissolved in diethyl ether (2.6 mL) at room temperature was added HCl 2N in diethyl ether (7.1 mL). The reaction mixture was stirred for 1.5 h then concentrated to dryness. The resulting solid was triturated with diethyl ether, collected and dried to give the title compound (138 mg, quantitative) as a brown oil.

出典