反応 #1701

反応方程式

diethyl 1-(6-chloro-1-oxoindan-2-yl)imidazole-2,4-dicarboxylate

ammonium acetate

acetic acid

→

ethyl 7-chloro-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-2-carboxylate

収率 61.7%

溶媒

acetonitrile

methanol

acetone

反応条件

後処理

1. 1
   洗浄After washing the precipitate with water
2. 2
   その他with methyl ethyl ketone, the solid obtained

実験手順

The procedure is as in Example 1 but starting from 5 g of diethyl 1-(6-chloro-1-oxoindan-2-yl)imidazole-2,4-dicarboxylate, 118 g of ammonium acetate and 190 ml of acetic acid. After washing the precipitate with water and then with methyl ethyl ketone, the solid obtained is first of all ground in acetonitrile and then in methanol and finally in acetone to obtain 2.7 g of ethyl 7-chloro-4,5-dihydro-4-oxo-10H-imidazo[1,2-a]indeno[1,2-e]pyrazine-2-carboxylate in the form of a brown solid melting above 260° C. (analysis % calculated C: 58.28, H: 3.67, Cl: 10.75, N: 12.74; % found C: 58.6, H: 3.4, Cl: 10.4, N: 13.1).

出典