反応 #169920

反応方程式

4-amino-N-(3-chloro-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide

N,N-diisopropylethylamine

benzyl isocyanate

→

desired product

収率 24.7%

4-Amino-N′-{[(benzylamino)carbonyl]oxy}-N-(3-chloro-4-fluorophenyl)-1,2,5-oxadiazole-3-carboximidamide

収率 24.7%

溶媒

dichloromethane

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated
2. 2
   その他purified by preparative LCMS

実験手順

A solution of 4-amino-N-(3-chloro-4-fluorophenyl)-N′-hydroxy-1,2,5-oxadiazole-3-carboximidamide (50 mg, 0.18 mmol) and N,N-diisopropylethylamine (64 μL, 0.37 mmol) in dichloromethane (2 mL) was treated with benzyl isocyanate (29 mg, 0.22 mmol) and stirred for 3 h. The reaction mixture was concentrated and purified by preparative LCMS to give the desired product (18 mg, 24%). LCMS for C17H15ClFN6O3 (M+H)+: m/z=405.0.

出典