反応 #169677

反応方程式

(2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-yl)-acetic acid 4-allyl-2-methoxy-phenyl ester

hydrochloric acid

→

solid

収率 107.0%

2-Hydroxy-succinic acid 4-(4-allyl-2-methoxy-phenyl)ester

収率 107.0%

溶媒

THF

反応条件

後処理

1. 1
   その他The solvent was evaporated to half volume, saturated with sodium chloride
2. 2
   抽出the product was extracted with ethyl acetate (2×850 mL)
3. 3
   乾燥The organic layer was dried over sodium sulphate
4. 4
   濃縮concentrated

実験手順

To a solution of (2,2-Dimethyl-5-oxo-[1,3]dioxolan-4-yl)-acetic acid 4-allyl-2-methoxy-phenyl ester (35.0 g, 0.10 mol) in THF (350 mL) was added 1N hydrochloric acid (350 mL) at room temperature (25° C.) and the mixture was stirred at same temperature over a period of 8 h. The solvent was evaporated to half volume, saturated with sodium chloride and the product was extracted with ethyl acetate (2×850 mL). The organic layer was dried over sodium sulphate and concentrated to obtain off-white solid (30.0 g, 98%).

出典