反応 #169670

反応方程式

niacin

L-proline methyl ester

N-methyl morpholine

EDC.HCl

→

product

収率 172.9%

1-(pyridine-3-carbonyl)-pyrrolidine-2-carboxylic acid methyl ester

収率 172.9%

溶媒

DCM

DCM

反応条件

後処理

1. 1
   洗浄washed with water (2×100 mL)
2. 2
   乾燥dried over sodium sulphate
3. 3
   その他Solvent was evaporated under reduced pressure

実験手順

To a solution of niacin (0.4 g 3.50 mmol) in DCM (10 mL) were added L-proline methyl ester (0.5 g, 3.21 mmol), N-methyl morpholine (1.1 mL, 0.10.5 mmol), EDC.HCl (1.2 g, 6.4 mmol) and catalytic amount of DMAP at ice temperature (0° C.). The mixture was allowed to stir at room temperature (25° C.) over a period of 2 h. The resulting mixture diluted with DCM (100 mL) washed with water (2×100 mL) and dried over sodium sulphate. Solvent was evaporated under reduced pressure to obtain product as yellow gummy oil (1.3 g).

出典