反応 #169391

反応方程式

Ethyl 4-chloroacetoacetate

cyclopropanecarboxamide

→

title compound

収率 50.0%

Ethyl (2-cyclopropyl-1,3-oxazol-4-yl)acetate

収率 50.0%

溶媒

toluene

1,4-dioxane

反応条件

後処理

1. 1
   その他then evaporated in vacuo
2. 2
   その他The crude solid was purified by column chromatography on silica gel (80:20 petroleum ether: EtOAc)

実験手順

Ethyl 4-chloroacetoacetate (20.0 g, 122.0 mmol) was added to cyclopropanecarboxamide (3.52 g, 41.5 mmol) in toluene (100 mL) and 1,4-dioxane (100 mL). The mixture was refluxed at 120° C. for 17 hours then evaporated in vacuo. The crude solid was purified by column chromatography on silica gel (80:20 petroleum ether: EtOAc) to afford the title compound as a white solid in 50% yield, 4.00 g.

出典