反応 #169095
ord-3ff3a25f083043bba883e7f082e9c364
反応方程式
反応条件
詳細条件
See reaction.notes.procedure_details.
後処理
- 1ろ過the reaction mixture was filtered through a pad of CELITE
- 2ろ過filter agent
- 3洗浄The pad was rinsed with acetonitrile
- 4濃縮the combined filtrates were concentrated under reduced pressure
実験手順
7-Bromo-3-nitro-N-(tetrahydro-2H-pyran-4-ylmethyl)quinolin-4-amine (20 g, 55 mmol) was dissolved in a mixture of acetonitrile (500 mL) and isopropyl alcohol (50 mL) and the solution was placed in a pressure bottle. Platinum on carbon (5%, 2 g) was then added and the reaction mixture was shaken under H2 at 48 PSI (3.3×105 Pa). After 2 hours, the reaction mixture was filtered through a pad of CELITE filter agent. The pad was rinsed with acetonitrile and the combined filtrates were concentrated under reduced pressure to give 7-bromo-N-(tetrahydro-2H-pyran-4-ylmethyl)quinoline-3,4-diamine which was carried forward without further purification assuming quantitative yield.