反応 #1689

反応方程式

HCl

phenethylamine

triethylamine

methyl chloroformate

→

title compound

収率 95.0%

N-Methoxycarbonylphenethylamine

収率 95.0%

溶媒

diethyl ether

THF

THF

反応条件

後処理

1. 1
   洗浄The organic layer was washed with water
2. 2
   乾燥dried (MgSO4)
3. 3
   ろ過filtered
4. 4
   濃縮the filtrate was concentrated in vacuo

実験手順

To a stirred solution of phenethylamine (75.2 mL, 0.6 mol) and triethylamine (83 mL, 0.6 mol) in THF (500 mL) was added slowly methyl chloroformate 46.2 mL, 0.6 mol) dissolved in THF (50 mL). After the reaction was stirred for an additional 1 h at room temperature, diethyl ether (2 L) and 1N HCl (800 mL) were added. The organic layer was washed with water, dried (MgSO4), filtered, and the filtrate was concentrated in vacuo to give a clear oil of pure title compound (102 g, 95%).

出典