反応 #1687650

反応方程式

morpholine

piperidine

hydrogen chloride

2,5-dichlorobenzoylchloride

anisole

diphenyl ether

→

2,5-dichlorobenzoylpiperidine

2,5-dichlorobenzoylmorpholine

溶媒

toluene

pyridine

toluene

benzene

toluene

反応条件

後処理

1. 1
   その他at 0-5° C.
2. 2
   その他The solid products obtained
3. 3
   その他upon quenching with water
4. 4
   その他are purified by recrystallization from toluene/hexanes
5. 5
   洗浄After washing away the pyridinium salt
6. 6
   その他any excess amine, the product is crystallized from the toluene solution

実験手順

A wide variety of 2,5-dichlorobenzoyl-containing compounds (e.g. 2,5-dichlorobenzophenones and 2,5-dichlorobenzamides) can be readily prepared from 2,5-dichlorobenzoylchloride. Pure 2,5-dichlorobenzoylchloride is obtained by vacuum distillation of the mixture obtained from the reaction of commercially available 2,5-dichlorobenzoic acid with a slight excess of thionyl chloride in refluxing toluene. 2,5-dichlorobenzophenones (e.g. 2,5-dichlorobenzophenone, 2,5-dichloro-4'-methylbenzophenone, 2,5-dichloro-4'-methoxybenzophenone, and 2,5-dichloro-4'-phenoxybenzophenone) are prepared by the Friedel-Crafts benzoylations of an excess of benzene or substituted benzenes (e.g. toluene, anisole, or diphenyl ether, respectively) with 2,5-dichlorobenzoylchloride at 0-5° C. using 2-3 mole equivalents of aluminum chloride as a catalyst. The solid products obtained upon quenching with water are purified by recrystallization from toluene/hexanes. 2,5-dichlorobenzoylmorpholine and 2,5-dichlorobenzoylpiperidine are prepared from the reaction of 2,5-dichloro-benzoylchloride and either morpholine or piperidine, respectively, in toluene with pyridine added to trap the hydrogen chloride that is evolved. After washing away the pyridinium salt and any excess amine, the product is crystallized from the toluene solution.

出典