反応 #1687640

反応方程式

Sodium hydrogen sulfide monohydrate

3 -(3-chloro-1,2,5-oxadiazol-4-yl) pyridine

Potassium carbonate

1-bromo-3-phenylpropane

→

title compound

3-(3-(3-phenylpropylthio)-1,2,5-oxadiazol-4-yl)pyridine

溶媒

DMF

Water

反応条件

後処理

1. 1
   workup.STIRRINGthe reaction mixture was stirred for additionally 24 h
2. 2
   抽出extracted with ether
3. 3
   乾燥The combined ether phases were dried
4. 4
   その他evaporated
5. 5
   その他Purification by column chromatography (SiO2, eluent: ethyl acetate/methylene chloride (1:1))

実験手順

Sodium hydrogen sulfide monohydrate (0.74 g, 10.5 mmol) was added to a solution of 3 -(3-chloro-1,2,5-oxadiazol-4-yl) pyridine (1.27, 7.0 mmol) in DMF (30 ml) at room temperature and the reaction mixture was stirred for 1 h. Potassium carbonate (2.0 g, 14.5 mmol) and 1-bromo-3-phenylpropane (2.4 g, 12 mmol) were added and the reaction mixture was stirred for additionally 24 h. Water (50 ml) was added and extracted with ether. The combined ether phases were dried and evaporated. Purification by column chromatography (SiO2, eluent: ethyl acetate/methylene chloride (1:1)) gave the title compound.

出典