反応 #1687625

反応方程式

65

3-Mercapto-5(3-pyridyl)-1,2,4-triazole

potassium hydroxide

methyl iodide

→

3-Methylthio-5-(3-pyridyl)-1,2,4-triazole

溶媒

water

ether

反応条件

後処理

1. 1
   その他The ether phase was separated
2. 2
   抽出the aqueous phase extracted with 3×100 ml of ether
3. 3
   乾燥The combined organic phases were dried over magnesium sulphate
4. 4
   その他Removal of the solvent in vacuo
5. 5
   その他gave a colorless solid, 66

実験手順

A solution of 20 g (0.100 mol) of 65 and 7.5 g (0.150 mol) of potassium hydroxide in 100 ml of water was mixed with a solution of 10 ml (0.160 mol) of methyl iodide in 100 ml of ether. After addition of 1 g of tetrabutylammonium hydrogen sulphate the mixture was stirred overnight at room temperature. The ether phase was separated and the aqueous phase extracted with 3×100 ml of ether. The combined organic phases were dried over magnesium sulphate. Removal of the solvent in vacuo gave a colorless solid, 66. Yield: 17.0 g (0.089 mol, 89%).

出典