反応 #1687622

反応方程式

12

2-Methyl-5-(3-pyridyl)-2H-tetrazole

hydrogen chloride

→

title product

収率 26.0%

2-Methyl-(3-piperidyl)-2H-tetrazole, hydrochloride

収率 26.0%

溶媒

acetone

ether

反応条件

後処理

1. 1
   その他until acidic reaction
2. 2
   ろ過The precipitate was filtered off
3. 3
   その他dried
4. 4
   workup.DISSOLUTIONdissolved in methanol (25 ml)
5. 5
   workup.ADDITION5% palladium on charcoal (0.6 g) was added
6. 6
   ろ過The catalyst was filtered off
7. 7
   その他the filtrate was evaporated to dryness
8. 8
   その他Crystallization from ethanol

実験手順

To a solution of 12 (1.93 g, 0.012 mol) in acetone (50 ml) was added hydrogen chloride in ether until acidic reaction. The precipitate was filtered off, dried, and dissolved in methanol (25 ml). 5% palladium on charcoal (0.6 g) was added, and the mixture was shaked overnight under 3 atm. of hydrogen pressure. The catalyst was filtered off and the filtrate was evaporated to dryness. Crystallization from ethanol yielded 0.63 g (0.0031 mol, 26%) of title product M.P. 168°-172° C. Anal. (C7H14ClN5) C, H, N.

出典