反応 #168443

反応方程式

methyl 3-ethylcyclopentanecarboxylate

LAH

→

(3-ethylcyclopentyl)methanol

溶媒

THF

反応条件

後処理

1. 1
   その他The reaction mixture was quenched with saturated Na2SO4
2. 2
   ろ過filtered through a pad of celite
3. 3
   洗浄washing with ethyl acetate
4. 4
   濃縮the filtrate was concentrated to dryness

実験手順

To a stirred solution of methyl 3-ethylcyclopentanecarboxylate (1.50 g, 9.61 mmol) in THF (10 mL) was added LAH (1 M in THF; 9.6 mL, 9.6 mmol) at 0° C., and the reaction mixture was stirred at 0° C. for 1 hour. The reaction mixture was quenched with saturated Na2SO4, filtered through a pad of celite, washing with ethyl acetate, and the filtrate was concentrated to dryness to afford (3-ethylcyclopentyl)methanol (mixture of cis and trans isomers).

出典