反応 #168338

反応方程式

Cyclopentene oxide

benzylamine

→

trans-2-(benzylamino)cyclopentanol

溶媒

EtOAc

反応条件

後処理

1. 1
   その他microwaved at 150° C. for 3 hours
2. 2
   温度The reaction mixture was then cooled
3. 3
   洗浄The organic layer was washed with water
4. 4
   乾燥dried over anhydrous Na2SO4
5. 5
   その他Evaporation of the solvent
6. 6
   その他in vacuo and purification on a silica gel column (0 to 20% MeOH/CH2Cl2)

実験手順

Cyclopentene oxide (5.0 g, 59.1 mmol), benzylamine (7.0 g, 65.3 mmol) and titanium isopropoxide (3.40 g, 12.0 mmol) were taken in a microwave vial and microwaved at 150° C. for 3 hours. The reaction mixture was then cooled and diluted with EtOAc (100 mL). The organic layer was washed with water and dried over anhydrous Na2SO4. Evaporation of the solvent in vacuo and purification on a silica gel column (0 to 20% MeOH/CH2Cl2) afforded trans-2-(benzylamino)cyclopentanol. MS APCl calc'd for C12H17NO [M+H]+ 192. found 192.

出典