反応 #168239

反応方程式

6-(3-bromophenyl)-4-hydroxy-2-(4-phenoxyphenyl)nicotinonitrile

phosphoryl trichloride

→

6-(3-bromophenyl)-4-chloro-2-(4-phenoxyphenyl)nicotinonitrile

反応条件

後処理

1. 1
   濃縮concentrated

実験手順

A mixture of 6-(3-bromophenyl)-4-hydroxy-2-(4-phenoxyphenyl)nicotinonitrile (38.8 mg, 0.070 mmol) and phosphoryl trichloride (0.5 mL, 5.38 mmol) was heated to 90° C. for 17 h, then concentrated to give crude 6-(3-bromophenyl)-4-chloro-2-(4-phenoxyphenyl)nicotinonitrile, which was used in the next reaction without purification. MS (ES+) m/z: 461, 463 (M+H); LC retention time: 4.821 min (analytical HPLC Method A).

出典