反応 #168180

反応方程式

4-Chloro-aniline

2-bromo-N,N-diethylethylamine hydrobromide

N,N-diisopropylethylamine

→

4-chloro-N-(2-(diethylamino)ethyl)benzenamine

溶媒

EtOAc

NaHCO3

toluene

反応条件

後処理

1. 1
   洗浄The organic layer was washed with H2O (1×20 mL)
2. 2
   乾燥dried (Na2SO4)
3. 3
   ろ過filtered
4. 4
   濃縮concentrated

実験手順

4-Chloro-aniline (0.5 g, 3.9 mmol) was added to a solution of 2-bromo-N,N-diethylethylamine hydrobromide (1.12 g, 4.3 mmol) and N,N-diisopropylethylamine (2 mL, 11.7 mmol) in toluene (7.8 mL). The mixture was stirred at room temperature for 5 hours. The mixture was then diluted with EtOAc (30 mL) and saturated NaHCO3 (20 mL). The organic layer was washed with H2O (1×20 mL), dried (Na2SO4), filtered and concentrated to give 4-chloro-N-(2-(diethylamino)ethyl)benzenamine as an oil which was used without purification. MS (APCI+) [M+H]+ 227.3.

出典