反応 #167935

反応方程式

racemic (cis)-tert-butyl 4-methoxy-3-methylpiperidine-1-carboxylate

TFA

→

racemic (cis)-4-methoxy-3-methylpiperidine 2,2,2-trifluoroacetate

溶媒

DCM

反応条件

後処理

1. 1
   濃縮The reaction mixture was then concentrated

実験手順

A solution of racemic (cis)-tert-butyl 4-methoxy-3-methylpiperidine-1-carboxylate (230 mg, 1.0 mmol) in DCM (2 mL) with TFA (0.23 mL, 3.01 mmol) was stirred at room temperature overnight. The reaction mixture was then concentrated to give racemic (cis)-4-methoxy-3-methylpiperidine 2,2,2-trifluoroacetate. 1H NMR (400 MHz, DMSO-d6) δ ppm 3.27 (s, 3 H), 3.01-3.09 (m, 1 H), 2.93-3.00 (m, 1 H), 2.81-2.93 (m, 1 H), 2.69-2.77 (m, 1 H), 1.90-2.08 (m, 2 H), 1.57-1.67 (m, 1 H), 0.90 (d, J=7.1 Hz, 3 H).

出典