反応 #167896

反応方程式

2-(4-fluorophenyl)-3-iodo-7,8-dimethyl-6-piperazin-1-ylimidazo[1,2-b]pyridazine

dimethylaminopyridine

di-tert-butyl carbonate

→

product

収率 78.4%

tert-Butyl 4-[2-(4-fluorophenyl)-3-iodo-7,8-dimethylimidazo[1,2-b]pyridazin-6-yl]piperazine-1-carboxylate

収率 78.4%

溶媒

tetrahydrofuran

反応条件

後処理

1. 1
   その他The solvent is then evaporated off
2. 2
   その他the solid obtained
3. 3
   その他is recrystallized from acetonitrile

実験手順

A solution of 0.70 g (1.55 mmol) of 2-(4-fluorophenyl)-3-iodo-7,8-dimethyl-6-piperazin-1-ylimidazo[1,2-b]pyridazine and 19 mg (0.16 mmol) of dimethylaminopyridine in 10 mL of tetrahydrofuran is treated with 0.41 g (1.9 mmol) of di-tert-butyl carbonate for 1 hour. The solvent is then evaporated off and the solid obtained is recrystallized from acetonitrile. 0.67 g of product is thus isolated after drying.

出典