反応 #1675547

反応方程式

dihydropyran

methyl 16-hydroxyhexadecanoate

p-toluenesulfonic acid

NaHCO3

→

methyl 16-(2-tetrahydropyranyloxy)hexadecanoate

溶媒

dichloromethane

反応条件

後処理

1. 1
   その他equipped with a stirrer and a dropping funnel
2. 2
   workup.ADDITIONAfter the completion of the addition
3. 3
   workup.STIRRINGthe mixture was stirred at room temperature for an hour
4. 4
   その他the reaction
5. 5
   ろ過After filtering
6. 6
   その他removing solvent under reduced pressure

実験手順

100.26 g (0.35 mol) of methyl 16-hydroxyhexadecanoate, 0.60 g (3.5 mmol) of p-toluenesulfonic acid and 350 ml of dichloromethane were introduced into a 1-l flask equipped with a stirrer and a dropping funnel. 32.39 g (0.385 mol) of dihydropyran was added dropwise thereto while stirring at 0° C. After the completion of the addition, the mixture was stirred at room temperature for an hour to thereby complete the reaction. Next, the reaction mixture was neutralized by adding 0.59 g (7 mmol) of NaHCO3. After filtering and removing solvent under reduced pressure; a crude product of methyl 16-(2-tetrahydropyranyloxy)hexadecanoate was obtained.

出典