反応 #167469

反応方程式

3-bromocarbazole

N-phenyl-9H-carbazol-3-boronic acid

ethylene glycol dimethyl ether

potassium carbonate

→

white solid

収率 80.8%

9-phenyl-3,3′-bi(9H-carbazole)

収率 80.8%

溶媒

toluene

toluene

反応条件

後処理

1. 1
   その他Into a 200 mL three-neck flask were put
2. 2
   その他to be degassed while the pressure
3. 3
   workup.STIRRINGThe mixture was stirred at 80° C. for 3 hours under a nitrogen stream
4. 4
   workup.STIRRINGthe mixture was stirred for about 30 minutes
5. 5
   洗浄the mixture was washed with water and saturated saline in this order
6. 6
   乾燥After the washing, the organic layer was dried with magnesium sulfate
7. 7
   ろ過filtered
8. 8
   濃縮the obtained filtrate was concentrated, so that an oily substance
9. 9
   その他was obtained
10. 10
    ろ過this solution was filtered through Florisil (a product of Wako Pure Chemical Industries, Ltd
11. 11
    濃縮The obtained filtrate was concentrated

実験手順

Into a 200 mL three-neck flask were put 2.5 g (10 mmol) of 3-bromocarbazole, 2.9 g (10 mmol) of N-phenyl-9H-carbazol-3-boronic acid, and 152 mg (0.50 mmol) of tri(ortho-tolyl)phosphine. The air in the flask was replaced with nitrogen. 50 mL of ethylene glycol dimethyl ether and 10 mL of potassium carbonate solution (2 mol/L) were added to the mixture. This mixture was stirred to be degassed while the pressure was reduced. After the degassing, 50 mg (0.2 mmol) of palladium(II) acetate was added. The mixture was stirred at 80° C. for 3 hours under a nitrogen stream. After the stirring, about 50 mL of toluene was added to the mixture and the mixture was stirred for about 30 minutes, and then the mixture was washed with water and saturated saline in this order. After the washing, the organic layer was dried with magnesium sulfate. The mixture was gravity filtered, and the obtained filtrate was concentrated, so that an oily substance was obtained. The obtained oily substance was dissolved in toluene, and this solution was filtered through Florisil (a product of Wako Pure Chemical Industries, Ltd., Catalog No. 540-00135), alumina, and Celite (a product of Wako Pure Chemical Industries, Ltd., Catalog No. 531-16855). The obtained filtrate was concentrated to give 3.3 g of a white solid, which was the object of the synthesis, in a yield of 80%. A synthetic scheme of Step 1 is shown in the following (Z-1).

出典