反応 #167363

反応方程式

Dioxane HCl

1-(4-methyl-pyridin-3-yl)-3-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzotriazol-5-yl]-imidazolidin-2-one

MeOH

→

product

収率 89.4%

1-(1H-Benzotriazol-5-yl)-3-(4-methyl-pyridin-3-yl)-imidazolidin-2-one Hydrochloride

収率 89.4%

溶媒

DCM

反応条件

後処理

1. 1
   濃縮The reaction mixture was concentrated
2. 2
   洗浄washed with ether
3. 3
   その他The solid formed
4. 4
   その他was collected
5. 5
   その他dried under reduced pressure

実験手順

Dioxane HCl (10 ml) was added to 1-(4-methyl-pyridin-3-yl)-3-[1-(2-trimethylsilanyl-ethoxymethyl)-1H-benzotriazol-5-yl]-imidazolidin-2-one (I-141a: 350 mg, 0.78125 mmol) and the resulting mixture was stirred room temperature for 12 hours. The reaction was monitored by TLC (10% MeOH in DCM). The reaction mixture was concentrated and washed with ether. The solid formed was collected and dried under reduced pressure to afford 230 mg of the product (89.4% yield).

出典