反応 #167290

反応方程式

1-naphthalen-2-yl-imidazolidin-2-one

5-bromo-nicotinic acid methyl ester

trans-1,2-diamino cyclohexane

potassium phosphate

→

product

収率 27.0%

5-(3-Naphthalen-2-yl-2-oxo-imidazolidin-1-yl)-nicotinic Acid Methyl Ester

収率 27.0%

溶媒

1,4-dioxane

反応条件

後処理

1. 1
   その他to afford the crude product
2. 2
   その他Purification by column chromatography on silica gel (80% EtOAc in hexane)

実験手順

Using the same reaction conditions as in Example 79, 1-naphthalen-2-yl-imidazolidin-2-one (I-79b: 100 mg, 0.4711 mmol) was reacted with 5-bromo-nicotinic acid methyl ester (112 mg, 0.5182 mmol), 1,4-dioxane (10 mL), copper iodide (11 mg), trans-1,2-diamino cyclohexane (22 mg) and potassium phosphate (200 mg, 0.9422 mmol) to afford the crude product. Purification by column chromatography on silica gel (80% EtOAc in hexane) afforded 44 mg of the product (26.99% yield).

出典