反応 #1672627

ord-4ee8761c431847b4bc4142ac07a1b402

反応方程式

CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine HCl
N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O
glutathione
C[Si](C)(O[*:2])[*:1]
polydimethylsiloxane
→
CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3
apomorphine

反応物

CN1CCc2cccc3c2[C@H]1Cc1ccc(O)c(O)c1-3.Cl
apomorphine HCl
N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(=O)O)C(=O)O
glutathione
C[Si](C)(O[*:2])[*:1]
polydimethylsiloxane
—
ethanolic solution

試薬

なし

反応条件

詳細条件
See reaction.notes.procedure_details.

後処理

  1. 1
    workup.ADDITIONmixing until the mixture

実験手順

An apomorphine transdermal patch formulation was prepared by adding 1 milliliter of a ethanolic solution of 20 mg/ml apomorphine HCl and 2.6 mg/ml glutathione to 2 g of polydimethylsiloxane 200 and mixing until the mixture congealed.

出典

DOI: 10.6084/m9.figshare.5104873.v1特許: US05939094uspto-grants-1999_08