反応 #167250

反応方程式

1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one

4-bromo-benzoic acid methyl ester

trans-1,2-diamino cyclohexane

potassium carbonate

→

4-[3-(4-Methyl-pyridin-3-yl)-2-oxo-imidazolidin-1-yl]-benzoic acid methyl ester

収率 91.6%

溶媒

1,4-dioxane

反応条件

後処理

1. 1
   その他to afford the crude product
2. 2
   その他Purification by column chromatography on silica gel (5% MeOH in DCM)

実験手順

Using the same reaction conditions as in Example 14, 1-(4-methyl-pyridin-3-yl)-imidazolidin-2-one (I-14b: 150 mg, 0.84650 mmol) was reacted with 4-bromo-benzoic acid methyl ester (182 mg, 0.84650 mmol), 1,4-dioxane (50 mL), copper iodide (16 mg, 0.084650 mmol), trans-1,2-diamino cyclohexane (29 mg, 0.2539 mmol) and potassium carbonate (468 mg, 3.3860 mmol) to afford the crude product. Purification by column chromatography on silica gel (5% MeOH in DCM) afforded 230 mg of 4-[3-(4-Methyl-pyridin-3-yl)-2-oxo-imidazolidin-1-yl]-benzoic acid methyl ester (91.6% yield).

出典